As an alternative to Cefuroxime-Metronidazole, the combination of Ceftriaxone and Metronidazole IV is allowed, if preferable due to local resistance patterns.
- dosage: Ceftriaxone 2000mg 1dd (IV) + Metronidazole 500mg 3dd (IV)
- dosage for children (<18jr):
- Ceftriaxone 100mg/kg/day, max. 2g/dag in 1 dose
- Metronidazol 30mg/kg/day, max. 1.5g/day in 3 doses
- total number of doses: in arm A (48h): 2 doses Ceftriaxone and 6 doses Metronidazole, in arm B (5d): 5 doses Ceftriaxone and 15 doses Metronidazole.
considering co-interventions, switching and prolonging/restarting antibiotics, the same applies as for Cefuroxime-Metronidazole.