The main objective of this trial is to investigate the optimum treatment duration with postoperative antibiotics after surgery for complex acute appendicitis.

We are evaluating whether a reduced course of 48 hours is as effective and safe as the standard treatment of 5 days.

If the reduced course is proven to be non-inferior, this may lead to less antibiotic use in the future. Potential benefits of less antibiotic use are less antimicrobial resistance, shorter length of hospital stay and lower hospital costs.