The primary endpoint of this trial is a composite endpoint of infectious complications related to appendectomy and mortality within 90 days after appendectomy.

Infectious complications include intra-abdominal abscess (IAA) and surgical site infection (SSI).

An IAA is defined as an infection that involves the abdominal part of the body deeper than the fascial/muscle layers that is opened or manipulated during the operative procedure. IAA can be diagnosed through imaging or during reintervention, through purulent drainage from a drain placed into the IAA, or isolation of organisms from a culture of the IAA. An SSI can be either deep or superficial, involving the skin, subcutaneous tissue and/or deep soft tissues of the incision. IAA and SSI are defined in more detail according to the Center for Disease Control (CDC) criteria in the full study protocol.