Appendicectomy (T0) – intraoperative diagnosis complex appendicitis? Be sure to record an image (static or video).
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Inclusion & randomization (T0 – 24u) – ’till 24h after surgery at the latest. Please make a note of the study number and allocated treatment arm in the patient dossier.
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Treatment arm A & B  (T0 – 48u/5dgn)  48 hours or 5 days of antibiotics afterappendicectomy: cefuroxime-metronidazole IV 1500/500mg 3dd. Discontinue after the allocated duration is finished. Only restart/prolong/switch antibiotics when indicated by additional laboratory/imaging tests.
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Discharge – According to local protocol. Please register: body temperature <38gr C; oral intake resumed; patient mobilizes independently/as before surgery; VAS pain score <4 under control with oral analgesia.
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Postoperative outpatient visit (2-4wkn) – According to local protocol.
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Cost effectiveness questionnaire (4wkn) – Sent out by the studycoordinator through email/regular post.
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Telephone follow-up (90dgn) – By studycoordinator.